Chromosome-autonomous feedback down-regulates meiotic DNA break competence upon synaptonemal complex formation
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چکیده
منابع مشابه
The Axial Element Protein DESYNAPTIC2 Mediates Meiotic Double-Strand Break Formation and Synaptonemal Complex Assembly in Maize.
During meiosis, homologous chromosomes pair and recombine via repair of programmed DNA double-strand breaks (DSBs). DSBs are formed in the context of chromatin loops, which are anchored to the proteinaceous axial element (AE). The AE later serves as a framework to assemble the synaptonemal complex (SC) that provides a transient but tight connection between homologous chromosomes. Here, we showe...
متن کاملPolo-like kinase-dependent phosphorylation of the synaptonemal complex protein SYP-4 regulates double-strand break formation through a negative feedback loop.
The synaptonemal complex (SC) is an ultrastructurally conserved proteinaceous structure that holds homologous chromosomes together and is required for the stabilization of pairing interactions and the completion of crossover (CO) formation between homologs during meiosis I. Here, we identify a novel role for a central region component of the SC, SYP-4, in negatively regulating formation of reco...
متن کاملThe synaptonemal complex has liquid crystalline properties and spatially regulates meiotic recombination factors
The synaptonemal complex (SC) is a polymer that spans ~100 nm between paired homologous chromosomes during meiosis. Its striated, periodic appearance in electron micrographs led to the idea that transverse filaments within this structure 'crosslink' the axes of homologous chromosomes, stabilizing their pairing. SC proteins can also form polycomplexes, three-dimensional lattices that recapitulat...
متن کاملThe CSN/COP9 Signalosome Regulates Synaptonemal Complex Assembly during Meiotic Prophase I of Caenorhabditis elegans
The synaptonemal complex (SC) is a conserved protein structure that holds homologous chromosome pairs together throughout much of meiotic prophase I. It is essential for the formation of crossovers, which are required for the proper segregation of chromosomes into gametes. The assembly of the SC is likely to be regulated by post-translational modifications. The CSN/COP9 signalosome has been sho...
متن کاملThe Synaptonemal Complex Component C(2)M Regulates Meiotic Crossing over in Drosophila
BACKGROUND The synaptonemal complex (SC) is a proteinaceous structure that forms between homologously paired meiotic chromosomes. Previous studies have suggested that the SC is required for meiotic crossing over in Drosophila. However, only one component of this structure, C(3)G, has been identified in Drosophila. RESULTS Mutations in c(2)M cause a reduced frequency of meiotic crossing over d...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2020
ISSN: 0890-9369,1549-5477
DOI: 10.1101/gad.342873.120